Serpin family H member 1 mRNA (SERPINH1 mRNA)

Serpin family H member 1 (SERPINH1) mRNA encodes Heat Shock Protein 47 (HSP47), a collagen-specific molecular chaperone residing in the endoplasmic reticulum (UniProt Consortium, 2023). HSP47 is indispensable for the maturation of various collagen types, as it stabilizes the triple helix structure and facilitates the transport of procollagen from the ER to the Golgi apparatus (Taguchi & Razzaque, 2007). In pathological states characterized by excessive scarring, such as liver cirrhosis and idiopathic pulmonary fibrosis, SERPINH1 expression is markedly increased, driving the overproduction of extracellular matrix (Ishikawa et al., 2017). Therapeutic strategies targeting the SERPINH1 mRNA involve the use of small interfering RNAs (siRNAs) to trigger the degradation of the transcript, thereby reducing the synthesis of the HSP47 protein. One notable drug candidate, BMS-986263 (formerly ND-L02-s0201), is a lipid nanoparticle-encapsulated siRNA designed to treat advanced liver fibrosis by silencing SERPINH1 in hepatic stellate cells (BMS, 2020).

Other names

Heat shock protein 47 mRNAHSP47 mRNAColligin mRNARheumatoid arthritis antigen A-47 mRNACBP1 mRNACBP2 mRNAgp46 mRNA

RNA interference (siRNA) targeting the SERPINH1 transcript to inhibit the translation of Heat Shock Protein 47 (HSP47), thereby reducing collagen synthesis and secretion.