Serrate RNA effector molecule homolog (SRRT)

Serrate RNA effector molecule homolog (SRRT, also known as ARS2) is a nuclear RNA-binding protein encoded by the human SRRT gene. It acts as a mediator between the mRNA cap-binding complex and primary microRNA processing machinery, supporting the delivery and stability of capped precursor miRNAs for RNAi gene silencing. SRRT/ARS2 also assists cell cycle progression around S phase and is crucial for neural stem cell maintenance by activating SOX2 transcription. The protein can modulate cellular sensitivity to arsenic but does not directly confer arsenic resistance in humans. Diseases linked with SRRT dysfunction include cerebral arteriopathy with subcortical infarcts and leukoencephalopathy and spondylocostal dysostosis. It functions mainly as a scaffold, binding capped RNAs and recruiting elements of the RNA processing and decay machinery. No drugs are currently available that target SRRT directly.

Other names

ARS2Arsenite-resistance protein 2Arsenite resistance proteinASR2Asr2SerrateArsenate resistance protein 2Arsenate resistance protein ARS2

Not applicable; no known drugs specifically modulate this protein directly. The molecule acts as a platform and scaffold for RNA-processing machinery and cap-binding complex.