Target intelligence / Profile preview

SERTA domain-containing protein 1 (SERTAD1)

Target: SERTAD1
Molecular classification: Transcription factor, Coregulator

Overview

SERTAD1 acts as a transcriptional coregulator at E2F-responsive promoters, integrating signals from PHD-domain and/or bromodomain-containing transcription factors to modulate gene expression. It plays a role in cell cycle regulation, immune signaling through NLRP3 inflammasome activation, and host-pathogen interactions, such as with classical swine fever virus.

Other names: SEI1TRIP-Br1CDK4-binding protein p34SEI1Transcriptional regulator interacting with the PHD-bromodomain 1

Biological functions

Transcriptional regulationCell cycle controlInflammasome activationE2F/DP-mediated transcriptional activity

Disease associations

CancerInfectionInflammation

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