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Target intelligence / Profile preview
Serum Albumin (Human)
- Molecular classification
- Protein, Transport protein, Plasma protein
01
Overview
Human serum albumin (HSA) is the most abundant protein in human blood plasma, constituting about half of the total serum protein. It is a highly water-soluble, globular, monomeric protein produced exclusively by the liver. HSA plays critical roles in maintaining oncotic pressure and pH balance in blood, as well as serving as a carrier for hormones, fatty acids, drugs, and other endogenous and exogenous compounds. Abnormal levels can indicate or contribute to disease states, and therapeutically purified HSA is used clinically for volume expansion or replacement therapy. HSA nanoparticles are also explored for targeted drug delivery.
- Other names
- AlbuminPRO1341PRO0903PRO0883FDAHANALBAHSA
02
Mechanism of action
N/A (Transport protein influencing drug pharmacokinetics and distribution)
03
Biological functions
Oncotic pressure maintenanceTransport of ligands (fatty acids, steroid hormones, thyroid hormones, bilirubin, drugs, metal ions)pH bufferingAntioxidant activityNitric oxide carrier
04
Disease associations
Liver disease (hypoalbuminemia)Kidney dysfunction (hypoalbuminemia, albuminuria)Nephrotic syndromeNutritional deficiency
05
Safety considerations
Potential for volume overload with therapeutic administrationHypersensitivity reactions (rare)
06
Interacting drugs
Many (due to drug binding and transport influencing pharmacokinetics)
07
Biomarkers
Serum albumin level (indicator of nutritional status, liver function, kidney function)Albuminuria (indicator of kidney disease)
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