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Target intelligence / Profile preview
Serum Alpha-Amylase (None)
- Target
- None
- Molecular classification
- Enzyme, Hydrolase
01
Overview
Serum alpha-amylase is an enzyme found predominantly in the blood, secreted mainly by the pancreas and salivary glands. It plays a crucial role in carbohydrate digestion by catalyzing the hydrolysis of α-1,4 glycosidic bonds in large polysaccharides such as starch and glycogen, breaking them down into smaller sugars like maltose and dextrins. It is primarily used in the diagnosis of acute pancreatitis, but serum lipase is now the preferred test due to improved sensitivity. Amylase is not considered a drug target.
- Other names
- Alpha-Amylaseα-AmylaseSerum AmylaseAmylase
02
Mechanism of action
N/A
03
Biological functions
Carbohydrate digestionHydrolysis of α-1,4 glycosidic bondsStarch breakdownGlycogen breakdown
04
Disease associations
Acute pancreatitisPancreatic disordersSalivary gland diseaseRenal impairmentMacroamylasemiaAbdominal inflammatory conditions
05
Safety considerations
False negatives in hyperlipidemia or alcohol-induced pancreatitisNon-specific elevations due to other conditionsLimited sensitivity compared to lipase
06
Biomarkers
Elevated serum amylase in pancreatitis
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