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Target intelligence / Profile preview
Serum Amyloid A Protein (SAA)
- Target
- SAA
- Molecular classification
- Apolipoprotein, Acute-phase protein
01
Overview
Serum amyloid A (SAA) proteins are a family of apolipoproteins primarily associated with high-density lipoprotein (HDL) in plasma. They are major acute-phase proteins whose serum concentrations increase dramatically during inflammation, infection, or trauma. SAA is mainly produced by hepatocytes and plays a role in modulating innate immunity, cholesterol homeostasis, and recruiting immune cells. Chronic elevation is linked to several diseases, including AA amyloidosis.
- Other names
- SAA1SAA2SAA4Acute-phase serum amyloid A
02
Biological functions
Acute phase responseCholesterol transportImmunomodulationRecruitment of immune cellsCytokine productionMatrix degradationInnate immunity modulation
03
Disease associations
AA AmyloidosisRheumatoid ArthritisAtherosclerosisInflammationMetabolic disorders
04
Safety considerations
Chronic elevation linked to amyloidosisPotential for organ dysfunction due to amyloid fibril formation
05
Biomarkers
Systemic inflammationDisease activity in rheumatoid arthritisRisk factor for AA amyloidosisMetabolic health status
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