Serum amyloid A2–serum amyloid A4 readthrough (SAA2-SAA4)

The SAA2-SAA4 readthrough gene locus on chromosome 11 produces a transcript derived from the fusion of the SAA2 and SAA4 genes. This read-through transcript leads to a protein combining elements of both SAA2 and SAA4. These genes belong to the serum amyloid A (SAA) family, which encodes highly conserved apolipoproteins involved in the acute-phase inflammatory response and lipid metabolism[1][2][5]. However, the specific biological function or clinical significance of the SAA2-SAA4 fusion protein has not been established, and it is not regarded as a receptor, enzyme, or conventional therapeutic target. Instead, the locus reflects a rare instance of natural read-through transcription and is mostly categorized for genomic annotation purposes rather than functional biology[3][5].

Other names

SAA2-SAA4 proteinSAA2-SAA4 read-through transcriptSAA2-SAA4SAA2-SAA4 gene