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Pentraxin 2 (PTX2)
- Target
- PTX2
- Molecular classification
- Pentraxin, Short Pentraxin, Classical Pentraxin, Glycoprotein
01
Overview
Pentraxin 2 (PTX2), also known as Serum Amyloid P Component (SAP), is a secreted serum glycoprotein and a member of the pentraxin superfamily. It is universally present as a non-fibrillar component in amyloid deposits and regulates the solubility of amyloid fibrils and protects them from degradation. It functions as an opsonin interacting with Fc gamma receptors. It is a potential therapeutic target for modulating immune responses or influencing plaque stability.
- Other names
- Serum Amyloid P ComponentSAP
02
Mechanism of action
Modulating immune responses or influencing plaque stability by targeting PTX2/SAP
03
Biological functions
OpsoninAmyloid regulationInnate immunity
04
Disease associations
Alzheimer’s diseasePrion diseasesType 2 diabetes mellitusSystemic amyloidosesNeurodegenerative disorders
05
Biomarkers
Amyloid plaques
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