Serum and other proteins

Serum and other proteins refers to the collective group of proteins found in blood serum, primarily consisting of albumin and various globulins such as alpha, beta, and gamma globulins. While not a specific therapeutic target in the traditional sense, these proteins are fundamental to the pharmacokinetic profile of nearly all systemic drugs. Serum albumin, the most abundant protein in this group, serves as a major carrier for hydrophobic molecules, including hormones, fatty acids, and many pharmaceutical agents. The interaction between drugs and these proteins determines the 'free fraction' of the drug, which is the portion available to interact with its intended therapeutic target. Consequently, variations in serum protein levels due to diseases like cirrhosis or nephrotic syndrome can lead to significant changes in drug efficacy and safety. Furthermore, the formation of a 'protein corona' on the surface of nanoparticles in the blood is a critical factor in the development of modern drug delivery systems.

Other names

Plasma proteinsSerum proteinsBlood proteinsCirculating proteinsSerum albumin and globulins

Non-specific reversible binding to albumin and globulins, influencing drug transport and free fraction concentration.