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Serum-glucocorticoid kinase (SGK1)
- Target
- SGK1
- Molecular classification
- Enzyme, Protein Kinase, Serine/Threonine Kinase, AGC Kinase Family
01
Overview
Serum-glucocorticoid kinase (SGK1) is a serine/threonine protein kinase belonging to the AGC family. It plays a central role in cellular stress response, regulating ion channels, transporters, cell survival pathways, hormone release, neuroexcitability, inflammation, cell migration, angiogenesis, wound healing, and metabolic processes. SGK1 expression is induced by serum, glucocorticoids, mineralocorticoids, gonadotropins, cytokines, and growth factors. Activation occurs via phosphorylation through PDK1 and mTORC2. Altered SGK1 expression/activity is linked to hypertension, diabetic neuropathy/nephropathy, ischemic injury, neurodegeneration, cardiac fibrosis/remodeling, and cancer progression/metastasis, making it a potential therapeutic target.
- Other names
- SGKSerum and glucocorticoid-regulated kinase 1SGKL
02
Mechanism of action
Inhibition or modulation of SGK1 activity.
03
Biological functions
Ion channel regulationTransporter regulationCell survivalApoptosisCell proliferationHormone release regulationNeuroexcitabilityInflammationCell migrationAngiogenesisWound healingGlucose uptakeGlycolysisStress response
04
Disease associations
HypertensionDiabetic neuropathyDiabetic nephropathyIschemic injuryNeurodegenerationCardiac fibrosisCardiac remodelingCancer progressionCancer metastasis
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