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Target intelligence / Profile preview
Serum-glucocorticoid regulated kinase 1 (SGK1)
- Target
- SGK1
- Molecular classification
- Enzyme, Serine/threonine protein kinase, AGC family kinase
01
Overview
Serum-glucocorticoid regulated kinase 1 (SGK1) is a serine/threonine protein kinase that plays a crucial role in regulating various cellular processes, including ion transport, cell survival, and stress responses. Its activation requires dual phosphorylation by mTORC2 and PDK1. Dysregulation of SGK1 has been implicated in several diseases, including hypertension, diabetes, cancer, and neurodegenerative disorders.
02
Biological functions
Ion channel regulationMembrane transporter regulationCell survivalCell proliferationApoptosisNeuroexcitabilityHormone releaseInflammation responseRenal sodium excretionProtein synthesisEndothelial cell proliferationStress responseNeuronal injury repairDNA damage responseOxidative stress adaptationSignal transduction
03
Disease associations
HypertensionDiabetic neuropathyIschemic injuryNeurodegenerative diseasesCancerMajor depressive disorderType II diabetes risk factors
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