Serum lipid (null)

Serum lipids refer to the collection of lipid molecules circulating in the bloodstream, including cholesterol, triglycerides, phospholipids, and lipoprotein-bound lipids. These molecules play essential roles in energy storage, cellular membrane structure, and signaling pathways, and act as precursors of steroid hormones and bile acids. Abnormalities in the concentrations and compositions of serum lipids are linked to major diseases, notably cardiovascular disease and metabolic disorders. The concentrations of specific serum lipid components (such as LDL, HDL, or triglycerides) are used in clinical diagnosis and monitoring, and are targeted by a variety of lipid-lowering drugs. Key facts: - "Serum lipids" is not a single molecular target, but rather a clinical collective term. - This group includes multiple molecular families with distinct roles and regulatory mechanisms. - Clinical measurement of serum lipids is a cornerstone of cardiovascular risk assessment, but it is not a molecular therapeutic "target" in the conventional sense. This entry is flagged as incorrect for use as a single molecular target.

Other names

Serum lipidsblood lipidscirculating lipids

Inhibition of cholesterol synthesis (statins) - Increased clearance of triglyceride-rich lipoproteins (fibrates) - Inhibition of intestinal absorption of cholesterol (ezetimibe) - Enhanced clearance of LDL via upregulation of LDL receptors (PCSK9 inhibitors)