Serum protein corona on DiR-labeled nanoparticle surface (PC)

The serum protein corona on DiR-labeled nanoparticle (DIR-NP) surfaces is a dynamic layer of adsorbed proteins that forms when these nanoparticles encounter biological fluids like blood or serum (Monopoli et al., 2012, Nature Nanotechnology). This corona essentially replaces the synthetic surface of the nanoparticle with a biological interface, which determines the nanoparticle's biological identity and governs its interactions with the mononuclear phagocyte system, cellular receptors, and the immune system (Walkey & Chan, 2012, Chemical Society Reviews). While the corona can facilitate cellular uptake through specific protein-receptor interactions, it often leads to the rapid clearance of nanoparticles from circulation or can mask targeting ligands, thereby reducing therapeutic efficacy (Nel et al., 2009, Nature Materials). In the context of DIR-NPs, which are frequently used for in vivo imaging and tracking, the protein corona significantly influences the fluorescence signal's distribution and the nanoparticle's eventual fate in the body (Cedervall et al., 2007, PNAS). Understanding the composition of this corona is critical for the successful translation of nanomedicines, as it significantly influences the safety and efficacy of the delivery system.

Other names

Nanoparticle-protein coronaBiomolecular coronaHard coronaSoft coronaProtein adsorption layerDiR-NP protein corona

Not applicable as the protein corona is a biological phenomenon affecting drug delivery systems rather than a target for therapeutic drugs.