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Target intelligence / Profile preview
Serum-stimulated 2 receptor (ST2)
- Target
- ST2
- Molecular classification
- Receptor, Interleukin-1 receptor family, Toll-like/IL-1-receptor superfamily
01
Overview
Serum-stimulated 2 receptor (ST2), also known as IL1RL1, is a member of the interleukin-1 receptor family. It exists in two main forms: a transmembrane receptor (ST2L) and a soluble form (sST2). ST2L binds to interleukin-33 (IL-33), triggering downstream signaling pathways involved in immune responses and cardioprotection. sST2 acts as a decoy receptor, modulating IL-33 availability. sST2 is a biomarker for heart failure.
- Other names
- IL1RL1Interleukin-1 receptor-like 1DER4T1FIT-1
02
Mechanism of action
sST2 acts as a decoy receptor, binding IL-33 and preventing its interaction with the membrane-bound ST2L receptor.
03
Biological functions
Signal transductionImmune responseTh2 differentiationCardioprotectionModulation of inflammation
04
Disease associations
Heart failureMyocardial infarctionAsthmaAllergic diseasesInflammation
05
Biomarkers
sST2 (soluble ST2) as a biomarker for heart failure severity and prognosis
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