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Target intelligence / Profile preview
Sestrin 2 (SESN2)
- Target
- SESN2
- Molecular classification
- Stress-inducible protein
01
Overview
Sestrin2 is a stress-inducible protein that plays a critical role in cellular responses to various stresses, including oxidative stress, endoplasmic reticulum (ER) stress, and metabolic disturbances. It acts as an intracellular leucine sensor and is involved in regulating key signaling pathways that control cell growth, survival, metabolism, autophagy, and inflammation. Its ability to regulate oxidative stress response makes it a promising biomarker and therapeutic target.
- Other names
- Hi95
02
Mechanism of action
Selective activator of the mTORC1 pathway via sestrin-mediated leucine sensing
03
Biological functions
Stress responseAntioxidant activityMetabolic regulationAutophagyMitophagyInflammation modulationCell survivalApoptosis preventionLeucine sensormTORC1 regulatorAMPK activator
04
Disease associations
Cardiovascular diseasesAtherosclerosisHeart failureHypertensionNeurological disordersStrokeNeurodegenerationMetabolic diseasesNonalcoholic fatty liver disease (NAFLD)Renal injuryAcute kidney injury (AKI)Chronic kidney disease (CKD)
05
Interacting drugs
NV-5138
06
Biomarkers
Oxidative stressInflammationCell survival
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