Sestrin-3 (SESN3)

Sestrin-3 (SESN3) is a member of the sestrin family of stress-induced proteins that regulates cellular responses to oxidative and genotoxic stress by decreasing intracellular reactive oxygen species levels[1][4]. It plays a crucial role in maintaining glucose and lipid homeostasis, modulating insulin sensitivity, and controlling lipid storage, with particular significance in metabolic tissues such as the liver[2][4]. SESN3 acts as a metabolic regulator through negative feedback of the mTORC1 signaling pathway and positive activation of mTORC2/Akt signaling, thereby influencing cellular metabolism and stress adaptation[2][4]. It also functions in neuroinflammation, modulating pro-inflammatory cytokine expression and has been linked to neurological disorders like epilepsy[3]. No specific drugs targeting Sestrin-3 are currently available, but its central regulatory functions make it an attractive candidate for future therapeutic intervention in metabolic, inflammatory, and neurodegenerative diseases[2][3][4].

Other names

Sestrin 3SESN3SEST3MGC29667sestrin-3

Not applicable (Direct mechanisms of action for drugs not established; SESN3 instead acts through regulation of mTORC1/2 pathways and modulation of oxidative stress[2][4])