SET binding factor 1 pseudogene 2 (SBF1P2)

SET binding factor 1 pseudogene 2 (SBF1P2) is a processed genomic pseudogene located on human chromosome 1:11877770-11880406[5]. It is homologous to the SET binding factor 1 gene (SBF1), a catalytically inactive phosphatase that is functionally implicated in neuronal autophagy and peripheral neuropathy—specifically Charcot-Marie-Tooth disease—via its parental gene, but SBF1P2 itself lacks coding capacity and is not translated into a functional protein[1][2][3][5]. Pseudogenes such as SBF1P2 are generally nonfunctional DNA elements resulting from duplication or retrotransposition events; some may act as non-coding regulatory RNAs, but there is no evidence to date that SBF1P2 has such activity[4]. It is not considered a therapeutic target in current biomedical research.

Other names

SBF1P2SBF1 pseudogene 2SET binding factor 1 pseudogene 2