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Target intelligence / Profile preview
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike glycoprotein (Spike protein)
- Target
- Spike protein
- Molecular classification
- Viral fusion protein, Type I membrane glycoprotein
01
Overview
The SARS-CoV-2 spike (S) protein is a large, trimeric, type I membrane glycoprotein essential for viral entry into host cells. It mediates attachment to host cells via ACE2 interaction through its RBD and fusion of the viral envelope with the host cell membrane. The spike protein is the primary target for neutralizing antibodies, diagnostics, therapeutics, and vaccines against COVID-19.
- Other names
- S proteinSARS-CoV-2 SpikeSpike glycoproteinCOVID-19 Spike Protein
02
Mechanism of action
Inhibition of viral entry by blocking ACE2 interaction or preventing membrane fusion
03
Biological functions
Receptor bindingMembrane fusionViral entryImmune evasion
04
Disease associations
InfectionCOVID-19 pathogenesis
05
Safety considerations
Antibody-dependent enhancement (ADE)Off-target effects of entry inhibitorsPotential for immune escape mutations
06
Interacting drugs
Neutralizing antibodies
1 more in the full profile.
07
Biomarkers
Spike protein antibody levelsRBD binding affinity
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