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Target intelligence / Profile preview
Sex Hormone-Binding Globulin (SHBG)
- Target
- SHBG
- Molecular classification
- Glycoprotein, Transport protein
01
Overview
Sex hormone-binding globulin (SHBG) is a glycoprotein primarily produced in the liver that binds to sex hormones, such as testosterone and estradiol, and regulates their bioavailability in the bloodstream. SHBG modulates the distribution of these hormones between free and bound states, influencing their access to target tissues. Its levels are affected by hormonal and metabolic factors, and its measurement is clinically relevant for evaluating disorders related to androgen and estrogen activity.
- Other names
- Sex steroid-binding proteinTestosterone-binding beta-globulinTestosterone-estrogen-binding globulinTestosterone-estradiol binding globulinTestis-specific androgen-binding proteinABPSBPTEBG
02
Mechanism of action
SHBG binds to sex hormones, modulating their bioavailability and access to target tissues.
03
Biological functions
Steroid hormone transportRegulation of sex hormone bioavailability
04
Disease associations
Polycystic ovary syndrome (PCOS)Type 2 diabetes mellitusEndometrial cancerHyperthyroidismHypogonadismHepatic cirrhosisHypothyroidism/myxedemaHyperprolactinemiaExcessive androgen activity syndromes
05
Safety considerations
Altered SHBG levels can indicate underlying endocrine or metabolic disorders.Drug interactions affecting SHBG levels.
06
Interacting drugs
Exogenous steroids
1 more in the full profile.
07
Biomarkers
SHBG serum levelsTestosterone/SHBG ratio
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