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Target intelligence / Profile preview
Sexual-stage Surface Protein Pfs25 (Pfs25)
- Target
- Pfs25
- Molecular classification
- Surface Protein
01
Overview
Sexual-stage surface protein Pfs25 from *Plasmodium falciparum* is an essential molecule expressed after fertilization during sexual reproduction inside mosquitoes. Its unique structure makes it both challenging as a vaccine target but also highly effective: antibodies targeting conformational epitopes on native/recombinant Pfs25 can prevent further parasite development within mosquitoes—thus blocking human-to-mosquito malaria transmission entirely. This has made it one of the most intensively studied targets for next-generation TBVs aiming at global malaria elimination efforts.
02
Mechanism of action
Antibody-mediated blockage of parasite development in the mosquito midgut
03
Biological functions
Mediates interaction with mosquito midgut lamininEssential for oocyst formationTarget for transmission-blocking antibodies
04
Disease associations
Infection
05
Safety considerations
Challenges in achieving correct protein folding and conformation during recombinant productionEnsuring elicited antibodies are functional and transmission-blocking
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