SGT1 assembly cochaperone of MIS12 kinetochore complex (SUGT1)

SGT1 assembly cochaperone of MIS12 kinetochore complex (SUGT1) is a highly conserved nuclear protein that acts as an essential cochaperone for the heat shock protein Hsp90. SGT1 is required for proper assembly and stability of the Mis12 complex at the kinetochore, which in turn is crucial for chromosome alignment and segregation during mitosis[1][2][3][5]. SGT1 interacts with Hsp90 to facilitate the assembly of the Mis12 complex and acts as an adaptor, stabilizing protein-protein interactions necessary for kinetochore function[1][2]. Its deficiency destabilizes the Mis12 complex, impairing microtubule binding and leading to chromosomal misalignment and cell cycle defects[1]. In addition to its core role in mitosis, SGT1 is involved in other cellular processes such as protein ubiquitination, innate immunity, and may contribute to cancer through its effects on chromosome stability and cell division control[2][3][5]. The protein contains a tetratricopeptide repeat (TPR) domain, a central CS domain, and a Sgt1-specific (SGS) domain, all crucial for its adaptor and cochaperone activities[2][6][8].

Other names

Protein SGT1 homologSGT1Protein 40-6-3Sgt1Suppressor of G2 allele of SKP1 homologMIS12 kinetochore complex assembly cochaperonesuppressor of G2 allele of SKP1putative 40-6-3 proteinSUGT1SGT1 homologS. cerevisiae homolog of SGT1