SH2-containing inositol 5-phosphatase 1 (SHIP1)

SHIP1 (SH2-containing inositol 5-phosphatase 1), encoded by the INPP5D gene, is a key enzyme predominantly expressed in hematopoietic cells. As an inositol polyphosphate-5-phosphatase, it hydrolyzes PI(3,4,5)P3 to PI(3,4)P2, acting as a negative regulator of PI3K signaling and immune cell activation. Its multi-domain structure, including SH2, PH-like, catalytic, and C2 domains, enables both enzymatic activity and adaptor functions, making it a critical modulator of various cellular processes including immune regulation, osteoclast differentiation, and macrophage programming. Therapeutic targeting of SHIP1 has potential implications for neurodegenerative diseases and inflammatory conditions.

Other names

INPP5DSIP-145p150Ship

SHIP1 functions as an inositol polyphosphate-5-phosphatase, converting PI(3,4,5)P3 to PI(3,4)P2. This action inhibits downstream signaling pathways, particularly the PI3K/AKT/mTOR pathway, thereby negatively regulating cell activation and inflammatory responses. SHIP1 also functions as an adaptor protein, modulating signaling through protein-protein interactions.