Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
SH2 domain-containing protein 3A (SH2D3A)
- Target
- SH2D3A
- Molecular classification
- Adapter protein with SH2 and Ras-GEF domains, SH2 domain protein, Ras guanine-nucleotide exchange factor domain superfamily
01
Overview
SH2 domain-containing protein 3A (SH2D3A) is a human protein encoded by the SH2D3A gene. It is an adapter protein featuring both an SH2 domain and a Ras guanine-nucleotide exchange factor (Ras-GEF) domain, enabling binding to phosphotyrosine residues and likely mediating interactions in signal transduction pathways, including possible involvement in the JNK cascade. SH2D3A interacts with proteins such as the epidermal growth factor receptor and belongs to a family of adapter proteins that couple phosphotyrosine signaling to small GTPase–mediated pathways. While SH2 domain proteins are broadly important in regulating cellular signaling, SH2D3A itself has no direct validation as a drug target or established roles in major diseases beyond weak associations with certain infectious encephalitides.
- Other names
- NSP1Novel SH2-containing protein 1UNQ175/PRO201SH23ASHEP1
02
Biological functions
Signal transduction involving SH2 domainsGuanyl-nucleotide exchange factor activityPhosphotyrosine residue bindingPossible involvement in JNK pathway activation
03
Disease associations
Eastern Equine Encephalitis (association)Western Equine Encephalitis (association)Other (limited direct evidence of disease relevance)
Beyond the preview
Go deeper on SH2 domain-containing protein 3A (SH2D3A).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on SH2 domain-containing protein 3A (SH2D3A).