SH2 domain-containing protein 4B (SH2D4B)

SH2 domain-containing protein 4B (SH2D4B) is a member of the family of proteins characterized by the presence of an Src homology 2 (SH2) domain—a structurally conserved motif of about 100 amino acids that mediates specific binding to phosphorylated tyrosine residues on other proteins[3][1]. SH2D4B is classified as an adaptor protein, meaning it primarily facilitates protein-protein interactions in intracellular signaling, rather than performing enzymatic or receptor functions itself[1]. It shares this classification with other SH2 domain-containing proteins that participate broadly in organizing and propagating intracellular signal transduction networks, especially those downstream of receptor tyrosine kinases[3][1]. There is no evidence that SH2D4B is currently a direct therapeutic target or has established roles in specific diseases or as a biomarker. Its tissue expression, according to The Human Protein Atlas, is detected in multiple tissues, suggesting a general role in cell signaling[2][4]. No drugs or targeted interventions are reported to interact with SH2D4B, nor are there known mechanisms of drug action specifically involving this molecule.

Other names

SH2D4BSH2 domain containing 4BSH2 domain-containing protein 4Bnovel SH2 domain-containing protein