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Target intelligence / Profile preview
SH2 Domain-Containing Protein Tyrosine Phosphatase (SHP2)
- Target
- SHP2
- Molecular classification
- Enzyme, Protein Tyrosine Phosphatase
01
Overview
SHP2 is a ubiquitously expressed cytosolic protein tyrosine phosphatase that plays a central role in cell signaling. It contains two N-terminal Src homology 2 (SH2) domains, a central catalytic phosphatase domain, and a C-terminal tail. The SH2 domains allow SHP2 to bind specifically to phosphorylated tyrosine residues on target proteins in response to various extracellular stimuli, modulating various signaling pathways involved in cell growth, differentiation, and immune responses. It is implicated in Noonan syndrome and various cancers.
- Other names
- PTPN11
02
Mechanism of action
Inhibition of SHP2 phosphatase activity, preventing dephosphorylation of target proteins
03
Biological functions
Signal transductionCell proliferationCell differentiationImmune response
04
Disease associations
CancerNoonan SyndromeDevelopmental DisordersAutoimmune Diseases
05
Safety considerations
Potential for off-target effects due to broad expressionDevelopment of resistance
06
Interacting drugs
SHP2 inhibitors (various, in development)
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