SH3 and multiple ankyrin repeat domains 2 pseudogene

SH3 and multiple ankyrin repeat domains 2 pseudogene (ENSG00000273858) is a genomic sequence that is highly similar to the functional SHANK2 gene but does not produce a functional protein[2][5][8]. Pseudogenes such as this arise through gene duplication or retrotransposition processes and, by definition, lack protein-coding potential—often due to disabling mutations or incomplete promoter regions. While some pseudogenes have been found to play regulatory roles (e.g., through competing endogenous RNA function), there is no documented evidence that this specific pseudogene has any functional role or therapeutic significance. It is important not to confuse this pseudogene with the functional SHANK2 gene, whose protein product participates in synaptic scaffolding and has been associated with neuropsychiatric conditions. The pseudogene is not a drug target, biomarker, or relevant for therapeutic modulation[2][5][8].