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Target intelligence / Profile preview
SH3 domain-binding protein 1 (SH3BP1)
- Target
- SH3BP1
- Molecular classification
- Enzyme (specifically Rho GTPase-activating protein, RhoGAP family)
01
Overview
SH3 domain-binding protein 1 (SH3BP1) is an enzyme classified as a Rho GTPase-activating protein (RhoGAP), which regulates the activity of Rho-type GTPases, including RAC1 and CDC42, by accelerating the conversion of their active GTP-bound state to the inactive GDP-bound state. SH3BP1 modulates cytoskeletal dynamics, cell motility, actin organization, epithelial junction formation, and phagocytosis, often serving as a negative regulator in these processes. Its cellular functions support proper cell migration, morphogenesis, and responses to semaphorin signaling, with established roles in the exocyst complex and interaction with Plexin-D1 and Rac signaling. Overexpression or dysregulation of SH3BP1 can promote metastasis in human liver cancer, and it is genetically associated with Aarskog-Scott syndrome.
- Other names
- SH3BP1ARHGAP433BP-1SH3 domain binding protein 1
02
Biological functions
Regulation of Rac protein signal transductionRegulation of actin cytoskeleton organizationRegulation of cell migration, motility, and epithelial junction formationNegative regulation of small GTPase mediated signal transductionAngiogenesis, morphogenesisPhagocytosis of large particlesCell protrusion organization
03
Disease associations
Cancer (promotes metastasis, especially in liver cancer tissues)Aarskog-Scott syndrome (association)Other (general roles in morphogenesis, possibly other disease processes)
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