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Target intelligence / Profile preview
SH3 domain-binding protein 5-like (SH3BP5L)
- Target
- SH3BP5L
- Molecular classification
- Guanine nucleotide exchange factor (GEF), Signal transduction protein, Other (non-receptor signaling protein, not a classic enzyme, transporter, ion channel, transcription factor, or histone modifier)
01
Overview
SH3 domain-binding protein 5-like (SH3BP5L) is a cytoplasmic guanine nucleotide exchange factor (GEF) that selectively activates Rab11 family GTPases, stimulating GDP release to permit GTP binding and thus activation of signaling pathways involved in membrane recycling, exocytosis, and cell division. SH3BP5L localizes mainly to recycling endosomes in mammalian cells, and its activity is critical for Rab11-mediated endosomal sorting and vesicular transport. The protein is predicted to play a role in intracellular signal transduction and shares structural and functional similarities with SH3BP5, forming part of a unique Rab11 GEF family. Disease association is currently limited to a genetic link with Bardet-Biedl syndrome 2, with no established roles in cancer, neurodegeneration, or inflammation. No approved drugs, biomarkers, or therapeutic safety concerns have been identified for SH3BP5L at present[1][2][5][6].
- Other names
- SH3BP5LKIAA1720UNQ2766/PRO7133SH3BP-5-likeSH3 domain-binding protein 5-like
02
Biological functions
Signal transductionIntracellular membrane trafficking (recycling endosomes)Regulation of Rab11-mediated vesicle transportCytokinesisExocytosis
03
Disease associations
Bardet-Biedl syndrome 2 (Gene-disease association; specific pathological roles are limited in current data)Other (no confirmed roles in common cancer, inflammation, neurodegeneration, infection, or cardiovascular disease as of now)
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