SH3 domain containing kinase binding protein 1 (SH3KBP1)

SH3 domain containing kinase binding protein 1 (SH3KBP1, also called CIN85) is an adapter/scaffold protein encoded by the human SH3KBP1 gene. It contains multiple Src homology 3 (SH3) domains, enabling it to mediate protein-protein interactions in diverse cellular processes. SH3KBP1 is essential for clathrin-dependent endocytosis, regulation of receptor tyrosine kinase pathways (like EGFR and MET), cytoskeletal rearrangement, cell adhesion, immune cell activation, and regulation of apoptotic signaling. It interacts with CBL and endophilins to promote receptor internalization, modulates TNF-alpha-induced apoptosis, and is implicated in cancer, immunodeficiency, and neurological disorders. No drugs directly target SH3KBP1, but its pathway involvement makes it a significant research target in oncology and immunology.

Other names

CIN85Cbl-interacting protein of 85 kDaCD2-binding protein 3 (CD2BP3)SH3 domain-containing kinase-binding protein 1Human Src family kinase-binding protein 1Src-related kinase binding protein-1HSB-1Ruk

Drugs targeting upstream or downstream pathways (e.g., EGFR inhibitors) may exert effects modulated by SH3KBP1, especially in receptor degradation or signal attenuation. No direct mechanisms for SH3KBP1-targeted drugs documented to date