SH3 domain-containing protein 19 (SH3D19)

SH3 domain-containing protein 19 (SH3D19) is a protein encoded by the SH3D19 gene in humans and contains multiple Src homology 3 (SH3) domains, which are modular domains critical for mediating protein–protein interactions via binding to proline-rich motifs on target proteins[2][3][7]. SH3D19 interacts with proteins such as EBP and members of the ADAM protein family, suggesting a role in modulating the signaling pathways associated with EGFR-ligand shedding[2][5][7]. It may also participate in suppression of Ras-mediated cellular transformation, regulation of cell morphology, and cytoskeletal organization, and is implicated in various vesicle trafficking processes[2][5]. There are no well-characterized drug interactions, biomarker use, or known therapeutic applications for this protein. Its relevance to disease appears limited to some reported associations, such as selective IgG deficiency, but it is not considered a canonical therapeutic target.

Other names

SH3D19EBPDKFZp434D0215EVE1KrynSH3P19Eve-1ADAM-binding protein Eve-1EEN-binding proteinEEN binding proteinSH3 domain protein D19