SH3GL interacting endocytic adaptor 1 (SGIP1)

SH3GL interacting endocytic adaptor 1 (SGIP1) is a brain-expressed endocytic adaptor protein involved in clathrin-mediated endocytosis and energy homeostasis. SGIP1 interacts with multiple endocytic and scaffold proteins (including endophilins, Eps15, AP-2, intersectin), modulating plasma membrane curvature and vesicle formation through its membrane phospholipid-binding domain, proline-rich domain, and C-terminal μ-homology domain. The alternative splicing variant SGIP1α (in mice) is essential for clathrin-mediated endocytosis due to additional regions in its MP domain driving membrane deformation and oligomerization. SGIP1’s role in neuronal signaling, energy regulation, and potential involvement in metabolic and neuropsychiatric disorders—as well as its value as a biomarker for hepatocellular carcinoma—underscore its functional importance, though it is not currently a direct therapeutic target[1][2][3].

Other names

SH3-containing GRB2-like protein 3-interacting protein 1DKFZp761D221Endophilin-3-interacting proteinSH3 domain GRB2 like endophilin interacting protein 1endophilin-3-interacting proteinSGIP1