SH3PXD2A antisense RNA 1 (SH3PXD2A-AS1)

SH3PXD2A antisense RNA 1 (SH3PXD2A-AS1) is a long non-coding RNA transcribed antisense to the SH3PXD2A gene. Located on chromosome 10, SH3PXD2A-AS1 is about 2023 base pairs in length. It is strongly upregulated in various cancers, such as colorectal cancer and non-small cell lung cancer, where it promotes cell cycle progression, proliferation, and tumor growth. Mechanistically, it interacts with protein partners such as DHX9 (to regulate FOXM1 expression) and p53 (to regulate p53 target genes), impacting oncogenic processes and cell fate decisions. In preeclampsia, SH3PXD2A-AS1 inhibits trophoblast invasion by recruiting CTCF to promoters and suppressing gene transcription. While not a classical receptor or enzyme, its emerging roles as an oncogenic lncRNA and disease biomarker make it a candidate for future RNA-based therapies in precision medicine.

Other names

SH3PXD2A-AS1SH3PXD2A antisense RNA 1

No approved drugs yet; mechanisms include modulation of cell cycle and proliferation via RNA interference or future lncRNA-targeting approaches.