SHANK2 antisense RNA 3 (SHANK2-AS3)

SHANK2 antisense RNA 3 (SHANK2-AS3) is a long non-coding RNA transcribed in the antisense orientation to the SHANK2 gene. It is non-protein coding and acts to regulate SHANK2 mRNA stability and translation in neuronal cells. SHANK2-AS3 is upregulated in patients with autism spectrum disorder, leading to reduced SHANK2 protein expression and notable changes in neuronal morphology, including decreased neurite outgrowth, suppressed neuronal proliferation, and increased apoptosis. These functional changes potentially contribute to neurodevelopmental pathologies, particularly autism spectrum disorder. The gene is also known as C11orf76, and is annotated with several aliases in genomic databases. To date, SHANK2-AS3 is not characterized as a druggable therapeutic target, nor is it directly targeted by known pharmacological agents[1][4][6].

Other names

C11orf76SHANK2 antisense RNA 3 (non-protein coding)Putative uncharacterized protein SHANK2-AS3

Acts as an antisense long non-coding RNA that binds to SHANK2 mRNA to form double-stranded RNA and suppresses SHANK2 gene expression at the post-transcriptional level