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Target intelligence / Profile preview
Shaw Potassium Channel
- Molecular classification
- Ion channel, Voltage-gated potassium channel
01
Overview
The Shaw potassium channel is a voltage-gated potassium (Kv) channel family member that is prominently expressed in neurons and is essential for enabling high-frequency, repetitive firing of action potentials. It plays critical roles in neuronal excitability by contributing to repolarization during action potentials. In Drosophila, they modulate pacemaker neuron activity that controls circadian locomotor behavior by affecting rhythmic neurotransmitter release from clock neurons. In mammals, the Shaw channels correspond to genes such as KCNC1–KCNC4.
- Other names
- Kv3 family potassium channelKCNC1KCNC2KCNC3KCNC4Kv3.1Kv3.2Kv3.3Kv3.4
02
Mechanism of action
Modulation of potassium ion flow across the cell membrane, affecting neuronal repolarization and excitability.
03
Biological functions
Regulation of neuronal excitabilityRepolarization during action potentialsModulation of pacemaker neuron activityRegulation of circadian rhythmsPotassium ion transmembrane transport
04
Disease associations
EpilepsyAtaxiaNeurodegenerative diseasesSleep disorders
05
Safety considerations
Potential for altering neuronal excitability leading to seizures or other neurological dysfunction.
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