SHC adaptor protein 2 (SHC2)

The SHC adaptor protein 2 (SHC2) is an intracellular adaptor protein, a member of the Shc family, that plays a critical role in coupling activated growth factor receptors—especially receptor tyrosine kinases and notably in neuronal cells—to downstream signal transduction pathways. SHC2 contains distinct Src homology 2 (SH2) and phosphotyrosine-binding (PTB) domains, enabling its interaction with phosphorylated tyrosine residues on activated receptors like neurotrophin Trk receptors and EGFR. Lacking intrinsic enzymatic activity, SHC2 functions as a critical scaffold for assembling signaling complexes, linking extracellular stimuli to cellular processes such as proliferation, differentiation, survival, and migration. Deregulation of SHC2 is implicated in diseases including cancer and neurodegeneration. Although SHC2 is a key intracellular adaptor involved in neuronal signal transduction and disease association, it is not typically considered a direct drug target or biomarker.

Other names

ShcBSHC-transforming protein 2SliShc2

no direct mechanism, as SHC2 is mostly targeted through modulation of associated pathways such as receptor tyrosine kinase inhibitors or downstream effectors