Shieldin complex subunit 2 pseudogene 1 (SHLD2P1)

Shieldin complex subunit 2 pseudogene 1 (SHLD2P1) is classified as a pseudogene in the human genome[1]. It is annotated as a non-functional copy of the parental gene SHLD2, which encodes a functional protein involved in DNA double-strand break repair as part of the shieldin complex. Unlike SHLD2, SHLD2P1 does not produce a functional protein product and is not known to play a direct molecular role in any biological process or disease pathology[1]. **Pseudogene status:** SHLD2P1 is a pseudogene, not a protein-coding gene, meaning it is typically considered a genomic remnant derived from a functional gene but is no longer translated into a functional protein[1]. It should not be confused with SHLD2, which encodes a key component of the DNA repair shieldin complex[3][4][5][7][8]. **Therapeutic relevance:** As a pseudogene, SHLD2P1 is not considered a therapeutic target such as a receptor, enzyme, transporter, or signaling molecule[1]. **Aliases:** Many alternative names reference its relation to the FAM35 gene family and pseudogene status but do not indicate it has a biochemical function[1]. **Disease and function:** There is no known functional or disease association for SHLD2P1, nor are there any known drugs targeting it, mechanisms of action, or biomarker utility[1]. **Incorrect status:** The query confuses the pseudogene SHLD2P1 with the functional gene SHLD2, which may be relevant for DNA repair, genome stability, and cancer biology, but SHLD2P1 itself is not a bona fide drug target[1][3][7][8]. If you are interested in the functional shieldin complex component, see “Shieldin complex subunit 2 (SHLD2)” for structured target information.

Other names

bA38L15.1FAM35BFAM35BPFAM35EPfamily with sequence similarity 35 member B, pseudogenefamily with sequence similarity 35, member A pseudogenefamily with sequence similarity 35, member E, pseudogeneSHLD2P1