Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Shiga Toxin (None)
- Target
- None
- Molecular classification
- AB5-type exotoxin, N-glycosidase
01
Overview
Shiga toxin is a potent cytotoxin produced by certain bacteria, most notably *Shigella dysenteriae* and Shiga toxin-producing *Escherichia coli* (STEC). It is responsible for severe gastrointestinal disease in humans, including bloody diarrhea and hemolytic uremic syndrome (HUS), a potentially fatal complication involving kidney failure. The toxin is an AB5-type exotoxin that binds to Gb3 glycolipids on host cells and inhibits protein synthesis, leading to cell death.
02
Mechanism of action
Inhibits protein synthesis via depurination of 28S rRNA.
03
Biological functions
Inhibition of protein synthesisCytotoxicityEndothelial cell damage
04
Disease associations
Bacillary dysenteryHemorrhagic colitisHemolytic uremic syndrome (HUS)
05
Safety considerations
Contraindication for antibiotic use in STEC infections due to increased toxin release.
Beyond the preview
Go deeper on Shiga Toxin (None).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Shiga Toxin (None).