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Target intelligence / Profile preview
Shiga toxin type 1 B subunit (Stx1B)
- Target
- Stx1B
- Molecular classification
- Toxin subunit, Glycolipid-binding protein
01
Overview
The Shiga toxin type 1 B subunit is a component of the Shiga toxin, a potent bacterial exotoxin. The B subunit forms a pentamer that binds specifically to globotriaosylceramide (Gb3), also known as CD77, which is present on the surface of target cells. This binding facilitates endocytosis and intracellular trafficking of the Shiga toxin A subunit, leading to inhibition of protein synthesis and cell death. While not directly toxic, StxB is essential for delivering the toxic A subunit into the cell.
- Other names
- StxBShiga toxin B subunitStx1 B subunit
02
Mechanism of action
Mediates binding to Gb3 receptor, facilitating endocytosis and intracellular trafficking of the Shiga toxin A subunit.
03
Biological functions
Receptor bindingEndocytosis mediationToxin traffickingCell entry
04
Disease associations
InfectionHemorrhagic colitisHemolytic uremic syndrome
05
Safety considerations
Potential for off-target effects due to Gb3 expression in normal tissues (when used for targeted drug delivery)Immunogenicity of the bacterial protein
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