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Target intelligence / Profile preview
Shiga Toxin Type 2 A Subunit (Stx2A)
- Target
- Stx2A
- Molecular classification
- Enzyme, Toxin, N-glycosidase
01
Overview
The Shiga toxin type 2 (Stx2) A subunit is the enzymatically active component of the Stx2 toxin, produced by certain strains of Escherichia coli and Shigella dysenteriae. It functions as an N-glycosidase, irreversibly inhibiting protein synthesis in eukaryotic cells by modifying 28S rRNA. Stx2A is a key virulence factor associated with severe diseases such as hemolytic uremic syndrome (HUS).
- Other names
- Stx2 A subunitShiga toxin 2 A chainStxA2Stx2a A subunit
02
Mechanism of action
N-glycosidase activity that removes an adenine residue from the sarcin-ricin loop (SRL) of eukaryotic 28S rRNA, inhibiting protein synthesis.
03
Biological functions
Protein synthesis inhibitionrRNA depurinationCell death
04
Disease associations
Hemolytic uremic syndrome (HUS)InfectionSTEC infection
05
Safety considerations
Renal toxicityNeurotoxicityHigh pathogenicity leading to HUS
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