Target intelligence / Profile preview

Shigella species (Shigella spp.)

Target
Shigella spp.
Molecular classification
Bacteria, Gram-negative bacteria, Enterobacteriaceae
01

Overview

Shigella is a genus of Gram-negative bacteria that causes shigellosis, a diarrheal illness. The four main species are Shigella dysenteriae, Shigella flexneri, Shigella boydii, and Shigella sonnei. These bacteria invade intestinal cells and produce toxins, leading to inflammation and diarrhea. Transmission occurs via the fecal-oral route. Antibiotic resistance is a growing concern.

Other names
ShigellaShigella dysenteriaeShigella flexneriShigella boydiiShigella sonnei
02

Mechanism of action

Antibiotic mechanisms vary depending on the drug (e.g., inhibition of protein synthesis, cell wall synthesis, etc.). Resistance mechanisms involve antibiotic inactivation or efflux.

03

Biological functions

InfectionPathogenesisVirulenceIntracellular survivalImmune evasion
04

Disease associations

ShigellosisBacillary dysenteryDiarrheaBloody diarrheaHemolytic uremic syndrome (HUS)
05

Safety considerations

Antibiotic resistanceHemolytic uremic syndrome (HUS)Invasive infection
06

Interacting drugs

Tetracycline

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