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Target intelligence / Profile preview
Shigella flexneri O-specific Polysaccharide (O-antigen (S. flexneri))
- Target
- O-antigen (S. flexneri)
- Molecular classification
- Polysaccharide, Lipopolysaccharide component, Bacterial surface antigen
01
Overview
The O-specific polysaccharide (O-antigen) of *Shigella flexneri* is a key component of the bacterium’s outer membrane lipopolysaccharide (LPS). It plays a critical role in serotype determination, immune recognition, and pathogenicity. The basic repeating unit for most serotypes is a tetrasaccharide composed of three L-rhamnose residues and one N-acetylglucosamine residue. Variations arise from chemical modifications such as glucosylation, O-acetylation, and phosphoethanolamine addition, which are responsible for generating different antigenic determinants that define each *S. flexneri* serotype. It is synthesized via the Wzy-dependent pathway. The O-antigen helps *S. flexneri* evade immune detection and is a target for phage therapy and diagnostic tools.
- Other names
- Shigella flexneri LPS O-antigenS. flexneri O-polysaccharideO-specific polysaccharide (S. flexneri)
02
Mechanism of action
Bacteriophages: O-antigen recognition and bacterial lysis. Antibodies: O-antigen binding and neutralization/opsonization.
03
Biological functions
Immune evasionSerotype determinationHost-pathogen interactionAdhesionBiofilm formation
04
Disease associations
ShigellosisInfectionInflammation
05
Safety considerations
Antigenic variation and serotype switching complicating vaccine developmentPotential for antibody-mediated enhancement of infectionDevelopment of phage resistance
06
Interacting drugs
Bacteriophages targeting O-antigen
1 more in the full profile.
07
Biomarkers
Serotype-specific O-antigen for diagnostic assays
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