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Target intelligence / Profile preview
Shigella flexneri serotype 2a O-antigen (S. flexneri 2a O-antigen)
- Target
- S. flexneri 2a O-antigen
- Molecular classification
- Bacterial surface polysaccharide, Lipopolysaccharide (LPS)
01
Overview
The Shigella flexneri serotype 2a O-antigen is a specific polysaccharide component of the bacterium’s outer membrane lipopolysaccharide (LPS). It serves as the primary determinant for serotyping within S. flexneri. The O-antigen plays a critical role in immune recognition, virulence, and epidemiology. It is essential for bacterial survival in the host, mediating resistance to complement-mediated killing and facilitating evasion of host immune responses.
02
Biological functions
Immune evasionSerotypingBacterial survivalResistance to complement-mediated killingImmune modulation
03
Disease associations
InfectionBacillary dysentery
04
Safety considerations
Antimicrobial resistanceEmergence of new serotypesGenetic plasticity
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