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Shigella sonnei Lipopolysaccharide O Antigen (None)
- Target
- None
- Molecular classification
- Polysaccharide, Lipopolysaccharide, O-antigen
01
Overview
The lipopolysaccharide (LPS) O antigen of *Shigella sonnei* is a surface-exposed polysaccharide that forms the outermost part of the bacterial LPS. It plays a crucial role in pathogenesis, immune evasion, and serotype specificity. The O antigen is composed of repeating disaccharide units of 2-acetamido-2-deoxy-L-altruronic acid (L-AltNAcA) and 2-acetamido-2-deoxy-L-fucose. Unlike other *Shigella*, *S. sonnei* expresses its O-antigen both as part of classical LPS and as a high-molecular-weight group 4 capsule (G4C). The genes encoding biosynthesis/export reside on the pSS virulence plasmid.
02
Mechanism of action
N/A
03
Biological functions
Immune evasionVirulence modulationSerotype specificityAdhesion
04
Disease associations
InfectionShigellosis
05
Safety considerations
Potential for immune responseVariability in O-antigen structure may affect vaccine efficacyAntibiotic resistance genes can be located on the pSS virulence plasmid encoding the O-antigen biosynthesis genes
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