Shigella sonnei O-antigen polysaccharide and outer membrane protein

**Shigella sonnei O-antigen polysaccharide** is a specific carbohydrate component of the lipopolysaccharide (LPS) layer on the bacterial outer membrane, with a distinct repeating unit structure that defines the serotype and is highly immunogenic[7]. It serves as the key protective antigen in immunity against *S. sonnei* and is a primary target for vaccine development, as antibodies to the O-antigen confer protective immunity[4][7]. **Outer membrane proteins (OMPs)** of *S. sonnei* are a diverse group of integral β-barrel proteins (e.g., OmpA, OmpC, PSSP-1) embedded within the bacterial outer membrane, carrying out essential roles in structural integrity, nutrient uptake, interaction with host cells, and pathogenesis[2][3][5][6]. Several OMPs are antigenic and can elicit immune responses, making them relevant both as potential vaccine targets and as candidate biomarkers for infection[3][6][9]. Both **O-antigen polysaccharide** and **outer membrane proteins** of *Shigella sonnei* are considered therapeutic/vaccine targets and play central roles in the pathogenesis and immunology of shigellosis[4][7]. The heterogeneity of these antigens poses challenges but also opportunities for diagnostic and vaccine design.

Other names

Shigella sonnei O-antigenS. sonnei O-antigen polysaccharideS. sonnei outer membrane proteinShigella sonnei OMPShigella outer membrane proteinS. sonnei OAgS. sonnei OMP

Vaccine-induced antibody response (primarily targeting O-antigen; some target OMPs)[4][7] Antibiotic action on cell envelope synthesis, not specific to these antigens