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Shigella sonnei O-specific Polysaccharide (None)
- Target
- None
- Molecular classification
- Polysaccharide, Lipopolysaccharide component, O-antigen
01
Overview
The Shigella sonnei O-specific polysaccharide (O-SP) is the outermost domain of the lipopolysaccharide (LPS) molecule found on the surface of S. sonnei. It plays a dual role as both an essential virulence factor and a protective antigen. The O-SP consists of repeating oligosaccharide units of 2-acetamido-2-deoxy-L-altruronic acid (L-AltNAcA) and 2-acetamido-4-amino-2,4-dideoxy-D-fucose (FucNAc4N). It is a primary target for immune responses and vaccine development against shigellosis. Conjugation of the O-SP to carrier proteins enhances immunogenicity.
02
Mechanism of action
Antibody neutralization, complement activation prevention
03
Biological functions
Virulence factorImmune evasionProtective antigen
04
Disease associations
InfectionShigellosis
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