Shigella species cell surface receptors

Shigella species cell surface receptors encompass a variety of bacterial molecules, including lipopolysaccharide (LPS) O-antigens and Type III Secretion System (T3SS) proteins like IpaB, IpaC, and IpaD, which are critical for the pathogen's ability to invade host cells. These surface components function as adhesins and invasins by interacting with host cell receptors such as CD44 and α5β1 integrins, triggering the cytoskeletal rearrangements necessary for bacterial entry into the intestinal epithelium. Additionally, certain species like Shigella dysenteriae produce Shiga toxin, which binds to the host cell surface receptor globotriaosylceramide (Gb3) to inhibit protein synthesis. As these molecules are exposed on the bacterial surface or are essential for virulence, they are the primary targets for the development of conjugate vaccines and neutralizing monoclonal antibodies aimed at preventing shigellosis. While traditional antibiotics target intracellular processes, modern therapeutic strategies focus on these surface-mediated mechanisms to provide serotype-specific or broad-spectrum protection against increasingly drug-resistant Shigella species.

Other names

Shigella surface antigensShigella invasion proteinsShigella outer membrane proteinsShigella virulence factorsShigella cell surface components

Neutralization of bacterial invasion and opsonization for immune clearance