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Shikimate dehydrogenase (SDH)
- Target
- SDH
- Molecular classification
- Enzyme, Oxidoreductase
01
Overview
Shikimate dehydrogenase (SDH) is an NAD(P)H-dependent oxidoreductase enzyme that catalyzes the reversible reduction of 3-dehydroshikimate to shikimate, using NADPH as a cofactor. This reaction constitutes the fourth step in the shikimate pathway, which is essential for the biosynthesis of aromatic amino acids—phenylalanine, tyrosine, and tryptophan—in plants, bacteria, fungi, algae, and some parasites. Animals and humans lack this pathway, making SDH an attractive target for herbicides and antimicrobial agents.
- Other names
- Shikimate 5-dehydrogenase3-Dehydroshikimate dehydrogenaseAroE
02
Mechanism of action
Inhibition of shikimate dehydrogenase activity, blocking the shikimate pathway and ultimately inhibiting the synthesis of aromatic amino acids.
03
Biological functions
Biosynthesis of aromatic amino acidsMetabolic pathway regulation
04
Disease associations
Infection (as a target for antimicrobial agents)
05
Safety considerations
Potential for off-target effects if inhibitors are not highly specific.
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