Shisa family member 2 (SHISA2)

Shisa family member 2 (SHISA2) is a protein that belongs to the Shisa family of transmembrane adaptor proteins. In humans, it is encoded by the SHISA2 gene located on chromosome 13. SHISA2 plays an important regulatory role in development, particularly in the maturation of presomitic mesoderm cells, by individually inhibiting both the fibroblast growth factor (FGF) and Wnt signaling pathways. These functions are essential for proper embryonic development and tissue differentiation. SHISA2 is mainly localized to membranes, including the endoplasmic reticulum membrane, and acts as a transmembrane modulator of receptor maturation, notably affecting immature forms of the Wnt receptor Frizzled and the FGF receptor. Although SHISA2 is not currently considered a therapeutic target (e.g., it is not an established receptor, enzyme, transporter, or typical drug target), mutations or altered expression patterns of SHISA2 have been linked to certain diseases, such as breast medullary carcinoma and movement disorders, but the precise mechanisms and potential as a biomarker or drug target remain unclear[3][7][8][2][4].

Other names

TMEM46C13orf13shisa-2 homolog