Shisa family member 4 (SHISA4)

Shisa family member 4 (SHISA4) is a membrane-associated protein belonging to the Shisa family, encoded by the SHISA4 gene and commonly referred to by multiple alternative names including TMEM58 and C1orf40[1][5]. SHISA4 has a predicted role as a scaffold/adaptor protein anchored in cell membranes, with several conserved cysteines following its transmembrane domain that may be lipid modified[3][4]. Functionally, SHISA4 has been implicated in the modulation of Wnt and FGF signaling pathways and may play a role in cell-surface signal transduction[2]. Notably, recent transcriptomic studies have identified SHISA4 as a biomarker for resistance to the chemotherapeutic agent 5-fluorouracil in colorectal cancer, supporting its importance in drug response and patient stratification[1]. The protein's expression appears to decline with age in muscle tissue, and genetic perturbation studies are ongoing to further elucidate its biological context[2][6][7]. There are no confirmed direct drug interactions or established roles in other diseases, but its association with cancer resistance is of particular therapeutic interest.

Other names

TMEM58C1orf40Protein shisa-4Transmembrane protein 58UNQ583/PRO1153hShisa4Shisa homolog 4

Association with chemotherapeutic resistance: SHISA4 expression modulates cellular sensitivity to 5-fluorouracil but no direct binding/mechanism established; implicated as a transcriptomic biomarker for nonresponse