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Target intelligence / Profile preview
Shisa family member 8 (SHISA8)
- Target
- SHISA8
- Molecular classification
- Other (Shisa protein family), Membrane-associated protein, Associated with AMPA receptor complex, Not classified as receptor, ion channel, enzyme, or transporter in major ontologies
01
Overview
Shisa family member 8 (SHISA8) is a membrane-associated protein predominantly expressed in the brain and adrenal gland, with lower levels in other tissues[4]. It is part of the AMPA receptor complex and is predicted to play a role in the regulation of short-term neuronal synaptic plasticity, possibly through the trafficking and modulation of AMPA-type glutamate receptors at synapses[1][2][3][4][5]. SHISA8 belongs to the Shisa protein family, is not classified as a receptor or classic druggable target, and is not currently implicated as a therapeutic target or clinically actionable biomarker. There is no reported direct involvement in major disease categories such as cancer, inflammation, or neurodegeneration, but its function in synaptic transmission suggests importance in neuronal signaling pathways[1][3][4].
- Other names
- C22orf17Orf26CTA-250D10.17protein shisa-8putative protein shisa-8shisa homolog 8
02
Biological functions
Regulation of short-term neuronal synaptic plasticityMay regulate trafficking and kinetics of AMPA-type glutamate receptorsLikely modulates synaptic transmission
03
Disease associations
Other (No direct disease link established; some gene-disease associations from genetic studies, but not confirmed in major disease pathways)
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